- Zinc supplementation in women at risk for intrauterine growth restriction (IUGR) is tied to altered markers of oxidative stress and insulin metabolism.
Why this matters
- IUGR affects 23.8% of all newborns in developing countries.
- In women with IUGR, markers for oxidative stress, inflammation, and membrane damage are increased.
- Zinc levels in women with IUGR are reported to be lower than in women without IUGR.
- Compared with controls, the intervention group had reduced high-sensitivity C-reactive protein (P<.001 and plasma malondialdehyde levels increased total antioxidant capacity>
- Insulin metabolism markers were improved with intervention.
- No difference in pulsatility index between groups.
- Randomized, double-blind, placebo-controlled clinical trial.
- Women included who were at risk for IUGR based on abnormal uterine artery Doppler waveform (n=52).
- Participants were randomly assigned into treatment group (233 mg zinc gluconate containing 30 mg zinc; n=26) vs placebo (n=26) for 10 weeks from 17 to 27 weeks of gestation.
- Fasting blood samples obtained at baseline and after 10 weeks of study.
- Funding: Vice-Chancellor for Research, KAUMS, Iran.
- Small sample size.
- Growth curves and birth weights not evaluated.
- IUGR diagnosed early in pregnancy; late IUGR not evaluated.