Zinc is tied to improved metabolic markers in pregnant women with abnormal Dopplers

  • Mesdaghinia E & al.
  • J Matern Fetal Neonatal Med
  • 04.07.2019

  • von Elisabeth Aron, MD, MPH, FACOG
  • Clinical Essentials
Der Zugang zum gesamten Inhalt dieser Seite ist nur Angehörigen medizinischer Fachkreise vorbehalten. Der Zugang zum gesamten Inhalt dieser Seite ist nur Angehörigen medizinischer Fachkreise vorbehalten.

Takeaway

  • Zinc supplementation in women at risk for intrauterine growth restriction (IUGR) is tied to altered markers of oxidative stress and insulin metabolism.

Why this matters

  • IUGR affects 23.8% of all newborns in developing countries.
  • In women with IUGR, markers for oxidative stress, inflammation, and membrane damage are increased.
  • Zinc levels in women with IUGR are reported to be lower than in women without IUGR.

Key results

  • Compared with controls, the intervention group had reduced high-sensitivity C-reactive protein (P<.001 and plasma malondialdehyde levels increased total antioxidant capacity>
  • Insulin metabolism markers were improved with intervention.
  • No difference in pulsatility index between groups.

Study design

  • Randomized, double-blind, placebo-controlled clinical trial.
  • Women included who were at risk for IUGR based on abnormal uterine artery Doppler waveform (n=52).
  • Participants were randomly assigned into treatment group (233 mg zinc gluconate containing 30 mg zinc; n=26) vs placebo (n=26) for 10 weeks from 17 to 27 weeks of gestation.
  • Fasting blood samples obtained at baseline and after 10 weeks of study.
  • Funding: Vice-Chancellor for Research, KAUMS, Iran.

Limitations

  • Small sample size.
  • Growth curves and birth weights not evaluated.
  • IUGR diagnosed early in pregnancy; late IUGR not evaluated.