- Management guidelines for early-onset adult (diagnosis age, 18-39 years) type 2 diabetes (T2D) are extrapolated predominantly from evidence in older individuals.
- The National Health Service England’s Research Needs Assessment 2018 included “interventions in the under 40s with T2D.”
Why this matters
- Early-onset adult T2D is increasingly prevalent and associated with poor long-term outcomes.
- These individuals may benefit from more aggressive interventions to halt development of diabetes complications.
- Review of study populations recruited to 37 cardiorenal outcomes trials, 28 trials from phase 3 programs of empagliflozin, liraglutide, and sitagliptin, and 25 prominent trials of diabetes self-management education and support (DSMES) or intensive lifestyle interventions.
- Funding: UK National Institute of Health Research; others.
- In 90 trials with 268,978 individuals, the overall mean age was 63 years.
- Proportions of patients ages 18-39 years:
- 0.97% in the 12 cardiorenal outcomes trials (n=56,518) that included individuals aged
- 4.87% in the phase 3 drug trials (n=18,974).
- 3.01% of 17 DSMES trials that included ages
- Overall, 29 trials excluded individuals age
- Working-age adults are more difficult to recruit for trials.