Which factors predict sepsis in patients with cellulitis?

  • Collazos J & al.
  • BMC Infect Dis
  • 12.03.2020

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Five factors are associated with sepsis development in patients with cellulitis, according to a prospective study.

Why this matters

  • Given the serious and potentially deadly risks associated with sepsis, identification of risk factors is needed.

Key results

  • 10.7% of patients developed sepsis.
  • In multivariate analysis, the following 5 factors were associated (ORs) with sepsis development:
    • Leukocyte count: 1.080 per 1000 cells/μL (P=.003).
    • Serum creatinine: 2.238 per mg/dL (P=.001).
    • Drawing of blood cultures: 2.984 (P=.003).
    • Modification of initial antimicrobial regimen: 2.154 (P=.03).
    • Maximum length of cellulitis: 1.029 per cm (P=.004).

Study design

  • 606 patients hospitalized with cellulitis were analyzed for development of sepsis and associated factors.
  • Funding: Infectious Diseases Working Group of the Spanish Society of Internal Medicine.

Limitations

  • Observational study design.
  • Heterogenous treatments used.