Which comorbidities are associated with vitiligo?

  • Hadi A & al.
  • J Am Acad Dermatol
  • 17.07.2019

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Patients with vitiligo are at increased risk of several diseases, including multiple sclerosis, IBD, and lymphoma, according to a cross-sectional study.

Why this matters

  • Few studies have investigated associations between vitiligo and other medical conditions; this study identifies a need for screening.

Key results

  • Patients with vitiligo had higher prevalence of hypothyroidism (1.65-fold increase; P<.0001 multiple sclerosis increase p rheumatoid arthritis idiopathic thrombocytopenic purpura seronegative pernicious anemia myasthenia gravis ibd lymphoma and systemic lupus erythematosus>
  • The most common disease was hypothyroidism (7.6% of patients).
  • Black patients had the highest rate of comorbid autoimmune disease (16.4%), followed by white patients (16.3%), Hispanic patients (15.7%), South Asian patients (8.4%), and East Asian patients (7.9%).
  • All statistically significant autoimmune disease associations were more prevalent in women compared with men.

Study design

  • 1487 patients with vitiligo were analyzed for prevalence of comorbidities compared with the general population.
  • Funding: None.

Limitations

  • Retrospective study design.