- Weight loss accompanying recent-onset diabetes is associated with increased pancreatic cancer risk.
Why this matters
- Pancreatic cancer is often diagnosed too late for cure.
- Clinicians may want to be alert to this risk association in the context of surveillance.
- Cohort study data from 112,818 women and 46,207 men with 4.5 million person-years in US follow-up studies, sent biennial questionnaires.
- Funding: Pussycat Foundation Helen Gurley Brown Presidential Initiative; NIH; Lustgarten Foundation; others.
- Pancreatic cancer occurred in 1116, for a rate of 25 per 100,000 person-years.
- Age-adjusted (a)HR (95% CI) for those with (vs without) diabetes based on diabetes onset duration:
- ≤4 years: 2.97 (2.31-3.82);
- >4 years: 2.16 (1.78-2.60).
- Compared with no weight loss, aHR (95% CI) for weight loss:
- 1-4 pounds: 1.25 (1.03-1.52);
- 5-8 pounds: 1.33 (1.06-1.66); and
- >8 pounds: 1.92 (1.58-2.32).
- Vs having no recent-onset diabetes and no 1-8 pounds weight loss, aHR (95% CI):
- 3.61 (2.14-6.10) with both;
- 6.75 (4.55-10.00) with weight loss >8 pounds.
- Incidence rate (95% CI) per 100,000:
- 16 (14-17) with no recent-onset diabetes+no 1-8 pounds weight loss;
- 91 (55-151) with both;
- 164 (114-238) with weight loss >8 pounds.
- Missing questionnaire data.
- Weight was assessed only every 2 years.
- Study population was mostly white, all health care professionals.