- The higher older adults’ levels of serum elaidic acid (an unsaturated trans fatty acid with 18:1 n-9 configuration), the greater their risks for all-cause dementia and Alzheimer’s disease (AD).
Why this matters
- Trans fatty acids, found in many food products, may be a modifiable risk factor for dementia, which currently has limited prevention and treatment options.
- All-cause dementia: 23.2%.
- Alzheimer’s disease: 15.2%.
- Vascular dementia: 6.3%.
- In analyses adjusted for traditional risk factors, the higher older adults’ serum elaidic acid levels, the higher their risks for:
- All-cause dementia (P for trend=.003).
- Alzheimer’s disease (P for trend=.02).
- Associations still significant after further adjustment for dietary factors, including total energy intake, intakes of saturated and polyunsaturated fatty acids:
- All-cause dementia (P for trend=.008).
- Alzheimer’s disease (P for trend=.04).
- Serum elaidic acid levels were not significantly associated with risk for vascular dementia.
- Prospective cohort study of 1628 Japanese community-dwelling older adults aged ≥60 years without dementia (Hisayama study).
- Main outcomes: all-cause dementia, Alzheimer’s disease, vascular dementia during median 10.2-year follow-up.
- Funding: Ministry of Education, Culture, Sports, Science and Technology of Japan; others.
- Nonrandomized nature of study.
- Potential residual and unmeasured confounding.
- Causality unknown.
- Unclear generalizability.