- Patients who underwent surgery for stage III small-cell lung cancer (SCLC) had significantly better OS vs those that did not receive surgery.
Why this matters
- Although surgery is standard treatment in stage I SCLC, chemotherapy and radiotherapy are recommended for stage III disease.
- 9606 patients diagnosed with stage III SCLC, 2004-2013, from the Surveillance, Epidemiology, and End Results database.
- Propensity matching of 234 patient pairs.
- Funding: Shandong First Medical University.
- 2.4% underwent surgery.
- The proportion of T1 stage patients and those with N0-N1 disease was higher in the surgical group than in the nonsurgical group (21.8% vs 11.1% and 26% vs 13.4%, respectively).
- OS was significantly better in surgical patients before (P<.001 and after propensity matching.>
- After multivariable analysis, surgery was significantly associated with better OS (HR, 0.651; P<.001>
- Retrospective study.