- Subclinical hyperthyroidism is associated with increased risk for fracture, whereas subclinical hypothyroidism is not, according to a systematic review and meta-analysis.
Why this matters
- The relationship between thyroid dysfunction and fracture risk was uncertain.
- Subclinical hyperthyroidism was associated with increased risk for any fracture (relative risk [RR], 1.17; P<.001 hip fractures p=".003)," spine and nonspine>
- Subclinical hypothyroidism was not significantly associated with risk for any fracture (RR, 1.14; P=.166), hip fracture (RR, 1.14; P=.068), spine fracture (RR, 0.95; P=.818), or nonspine fracture (RR, 1.09; P=.277).
- Subclinical hyperthyroidism was associated with reduced distal forearm bone mineral density (BMD) in women (P=.039) and lower ultradistal forearm BMD in men (P=.031) and women (P=.027).
- Subclinical hypothyroidism was associated with increased femur neck BMD in women (P=.026).
- 24 studies (313,557 participants) were included in the meta-analysis.
- Funding: Pudong New Area Health System of Shanghai.
- Heterogeneity between included studies.