Severe cough common in lung cancer patients

  • Amélie Harle AS & al.
  • Chest
  • 12.10.2018

  • von Kelli Whitlock Burton
  • Studien – kurz & knapp
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Takeaway

  • More than 60% of patients with lung cancer reported a cough severe enough to warrant treatment, with cough severity scores exceeding those reported in COPD or asthma.

Why this matters

  • There is a lack of data on cough prevalence, severity, effect, clinical associations, causes, and treatment in patients with lung cancer.

Study design

  • Longitudinal, observational study.
  • 177 patients with lung cancer and cough.
  • Funding: National Institute for Health Research; others.

Key results

  • 62% reported that their cough was severe enough to warrant treatment; 52% classified their cough as grade 1, 47% grade 2, and 1% grade 3.
  • Only 15% reported using antitussives at study onset.
  • 36.2% of patients reported that cough began after lung cancer diagnosis.
  • COPD, smoking history, and cancer characteristics (stage, histology, etc.) were not associated with cough severity or effect.
  • On univariate analysis, reflux disease (P<.001 nausea and use of antitussives at study onset were significantly associated with cough severity remained days.>
  • On univariate analysis, the use of opioids (P=.04) and antitussives (P<.001 were associated with improvement in cough severity at days.>

Limitations

  • Single-group, single-institution study.