Rotavirus vaccination shows no ties to pediatric T1D risk

  • Glanz JM & al.
  • JAMA Pediatr
  • 09.03.2020

  • von Emily Willingham, PhD
  • Clinical Essentials
Der Zugang zum gesamten Inhalt dieser Seite ist nur Angehörigen medizinischer Fachkreise vorbehalten. Der Zugang zum gesamten Inhalt dieser Seite ist nur Angehörigen medizinischer Fachkreise vorbehalten.

Takeaway

  • Rotavirus vaccination is not linked to pediatric type 1 diabetes (T1D) risk, according to the findings of this large cohort study.

Why this matters

  • This vaccine is linked to steeply reduced rates of hospitalization for acute gastroenteritis and decreased mortality.
  • Rotavirus infection has been posited as a risk factor for T1D, raising suspicions about the live attenuated vaccine.

Key results

  • Median follow-up, 5.4 (interquartile range, 3.8-7.8) years.
  • Total person-time follow-up in years was 2,253,879.
  • The cohort of 386,937 had 464 cases of T1D (415 fully exposed, 32 partially exposed, 17 unexposed).
  • T1D incidence rates:
    • Fully exposed: 20.0 cases/100,000 person-years.
    • Partially exposed: 31.2 cases/100,000 person-years.
    • Unexposed: 22.4 cases/100,000 person-years.
  • Children with full exposure to rotavirus vaccination vs unexposed had no increased risk for T1D (adjusted HR [aHR], 1.03; 95% CI, 0.62-1.72).
  • Children with partial exposure vs no exposure also had no increased risk (aHR, 1.50; 95% CI, 0.81-2.77).

Study design

  • Retrospective data from US Vaccine Safety Datalink for children born January 1, 2006-December 31, 2014.
  • Funding: CDC.

Limitations

  • Not followed through complete age range of peak T1D incidence (10-14 years).
  • Small numbers of unexposed.