- Rotavirus vaccination is not linked to pediatric type 1 diabetes (T1D) risk, according to the findings of this large cohort study.
Why this matters
- This vaccine is linked to steeply reduced rates of hospitalization for acute gastroenteritis and decreased mortality.
- Rotavirus infection has been posited as a risk factor for T1D, raising suspicions about the live attenuated vaccine.
- Median follow-up, 5.4 (interquartile range, 3.8-7.8) years.
- Total person-time follow-up in years was 2,253,879.
- The cohort of 386,937 had 464 cases of T1D (415 fully exposed, 32 partially exposed, 17 unexposed).
- T1D incidence rates:
- Fully exposed: 20.0 cases/100,000 person-years.
- Partially exposed: 31.2 cases/100,000 person-years.
- Unexposed: 22.4 cases/100,000 person-years.
- Children with full exposure to rotavirus vaccination vs unexposed had no increased risk for T1D (adjusted HR [aHR], 1.03; 95% CI, 0.62-1.72).
- Children with partial exposure vs no exposure also had no increased risk (aHR, 1.50; 95% CI, 0.81-2.77).
- Retrospective data from US Vaccine Safety Datalink for children born January 1, 2006-December 31, 2014.
- Funding: CDC.
- Not followed through complete age range of peak T1D incidence (10-14 years).
- Small numbers of unexposed.