Psoriasis tied to excess mortality risk in NHANES analysis

  • Semenov YR & al.
  • J Am Acad Dermatol
  • 12.08.2019

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Psoriasis is associated with increased mortality risk after controlling for demographics, smoking, and comorbidities, according to a retrospective analysis of the National Health and Nutrition Examination Surveys (NHANES).

Why this matters

  • Few studies have analyzed the independent mortality risk associated with psoriasis.

Key results

  • Patients with psoriasis had a higher overall mortality rate compared with patients without psoriasis (4.6% vs 2.2%; P=.003).
  • Psoriasis was associated with higher age-adjusted mortality rates per 1000 patient-years resulting from cancer (3.633 vs 1.371; P=.031) and pneumonia (1.164 vs 0.108; P=.004)
  • In mediation analysis, increased risk for death in psoriasis was mediated partially by cardiovascular disease (15.5%), chronic obstructive pulmonary disease (8.7%), cancer (11.7%), diabetes (5.9%), chronic kidney disease (4.2%), and stroke (4.7%).
  • Psoriasis was associated with increased mortality risk in multivariate analysis adjusted for demographics, smoking, and comorbidities (HR, 1.99; P=.047).

Study design

  • 13,031 subjects, 2.7% with psoriasis, were analyzed for mortality risk over the course of a median follow-up of 50.2 months.
  • Funding: None.

Limitations

  • Retrospective study of large database.