Psoriasis tied to elevated risk for mental disorders in Danish study

  • Leisner MZ & al.
  • JAMA Dermatol
  • 08.05.2019

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Psoriasis is associated with a broad spectrum of mental disorders, including vascular dementia, schizophrenia, bipolar disorder, unipolar depression, generalized anxiety disorder, and personality disorder, according to a Danish population study.

Why this matters

  • This study supports earlier research linking psoriasis with mental disorders but includes a wider spectrum of psychiatric diseases.

Key results

  • 5- and 10-year cumulative incidences of any mental disorder were 2.6% and 4.9%, respectively.
  • Psoriasis was associated with increased risk for:
    • vascular dementia (HR, 1.73; 95% CI, 1.21-2.47);
    • schizophrenia (HR, 1.64; 95% CI, 1.01-2.65);
    • bipolar disorder (HR, 2.33; 95% CI, 1.59-3.41);
    • unipolar depression (HR, 1.72; 95% CI, 1.49-1.98);
    • generalized anxiety disorder (HR, 1.88; 95% CI, 1.08-3.30);
    • personality disorders (HR, 2.06; 95% CI, 1.55-2.73).
  • Risk for mental disorders was higher in patients with short-term education (HR, 2.18; 95% CI, 1.95-2.44) compared with patients with medium- (HR, 1.45; 95% CI, 1.26-1.67) and long-term education (HR, 1.40; 95% CI, 1.11-1.78).

Study design

  • 13,675 patients with psoriasis were analyzed for mental disorder risk.
  • Funding: Psoriasis Forskningsfonden.

Limitations

  • Cross-sectional study of large registry.