Psoriasis incidence, severity correlate with metabolic risk factors

  • Hajiebrahimi M & al.
  • Clin Epidemiol
  • 01.01.2020

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • The incidence and severity of psoriasis are associated with metabolic risk factors such as hypertension, hypercholesterolemia, and diabetes mellitus, according to a population-based study.

Why this matters

  • This study suggests that patients with psoriasis should be monitored for metabolic risk factors.

Key results

  • Patients with psoriasis had increased risk (all HRs; 95% CIs) for hypertension compared with control participants:
    • Mild psoriasis: 1.29 (1.27-1.32).
    • Moderate psoriasis: 1.35 (1.32-1.38).
    • Severe psoriasis: 1.73 (1.64-1.82).
  • Patients with psoriasis had increased risk for hypercholesterolemia compared with control participants:
    • Mild psoriasis: 1.34 (1.31-1.38).
    • Moderate psoriasis: 1.32 (1.28-1.36).
    • Severe psoriasis: 1.58 (1.47-1.70).
  • Patients with psoriasis had increased risk for diabetes mellitus compared with control participants:
    • Mild psoriasis: 1.60 (1.55-1.65).
    • Moderate psoriasis: 1.67 (1.60-1.75).
    • Severe psoriasis: 2.25 (2.05-2.47).

Study design

  • Patients with psoriasis (3252 severe, 14,903 moderate, and 29,434 mild) from the national Swedish registers were included and matched 1:10 with con­trol participants.
  • Funding: Karolinska Institutet, Janssen Pharmaceuticals.

Limitations

  • Retrospective study of large databases.