- The incidence of frailty was significantly higher among US adults aged ≥65 years who use or co-use prescription medications for pain and/or insomnia.
- Nearly 80% of those who used both prescription medications for pain and insomnia met the criteria for frailty compared with just 30% of nonusers.
Why this matters
- Frailty is independently associated with loss of independence, increased use of healthcare resources, and mortality.
- 7201 nonfrail individuals from the Health and Retirement Study cohort (age, ≥65 years) with self-reported prescription drug use for pain and sleep.
- Funding: National Institute on Aging.
- 37.8% of individuals became frail during the study period.
- Cumulative incidence of frailty at 8 years in individuals with prescription drug use for pain and sleep, 60.6%; drug use for pain only, 50.9%; drug use for sleep only, 45.8%; and no drug use, 34.1%.
- Prevalence of frailty by prescription drug use: co-use, 78.8%; drug use for pain only, 58.5%; drug use for sleep only, 47.6%, and no drug use, 29.9%.
- Observational study.
Coauthored with Chitra Ravi, MPharm