Prescribing nonpalliative opioids for COPD patients increases mortality risk

  • Viglino D & al.
  • Sci Rep
  • 19.03.2020

  • von Kelli Whitlock Burton
  • Clinical Essentials
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Takeaway

  • Patients with COPD who receive opioids for acute pain in the emergency department have a significantly higher risk for invasive ventilation, ICU admission, and death, according to study in medical centers in France and Canada.

Why this matters

  • The prescription of nonpalliative opioids for patients with COPD increased significantly between 2008 and 2014.

Study design

  • Study of 7799 patients (ages >40 years) with COPD who visited an emergency department during 2008 and 2014.
  • Outcomes: invasive ventilation and death.
  • Funding: Agir pour les maladies chroniques; E-health and trajectories medicine.

Key results

  • Overall, 16.9% of patients were prescribed opioid drug.  
  • Opioid prescriptions were significantly increased during study period (13.8% to 22.2%; P<.01>
  • Opioid administration to patients with COPD significantly (P
  • Invasive ventilation: 3.41.
  • ICU admission: 1.81.
  • Death: 5.09.

Limitations

  • Spirometric/radiological tests were not conducted for COPD diagnosis.