- Children born at term to mothers with preeclampsia have increased odds for ADHD, autism, epilepsy, and intellectual disability.
Why this matters
- Few studies have separated preterm from term births in examining these outcomes.
- The direction of and timing of the association are unknown.
- Mothers of 2.9% of the cohort had preeclampsia.
- With a mean 14.0-year follow-up, relative to unexposed children, exposed children had elevated odds (aORs; 95% CIs) for:
- ADHD: 1.18 (1.05-1.33).
- Autism: 1.29 (1.08-1.54).
- Epilepsy: 1.50 (1.16-1.93).
- Intellectual disability: 1.50 (1.13-1.97).
- Odds of cerebral palsy were marginally elevated: aOR, 1.30 (95% CI, 0.94-1.80).
- Odds of vision/hearing loss were not significantly elevated.
- Findings were similar, but with stronger associations for cerebral palsy and vision/hearing loss in analyses, including both term and preterm births.
- Norwegian prospective, population-based cohort study of 980,560 term singleton infants.
- Main outcome: neurodevelopmental conditions.
- Funding: Intramural Research Program of NIH; National Institute of Environmental Health Sciences; Western Norwegian Regional Health Authority.
- Possible ascertainment bias toward cases of more severe exposure, outcomes.
- Unknown, unmeasured confounding.
- Lack of information on preeclampsia duration, severity.
- No causation established, direction or mediators of associations not known.