- About 6% of patients with ischemic stroke who receive reperfusion therapy develop seizures, regardless of the type of therapy.
Why this matters
- Balance of harms and benefits may influence the choice of reperfusion therapy.
- Patients experiencing seizure after stroke have increased risk for poor outcome and death.
- Pooled incidence of poststroke seizures was 5.9%.
- Incidences by acute reperfusion therapy type:
- 6.1% with intravenous thrombolysis (IVT).
- 5.9% with mechanical thrombectomy.
- 5.8% with both.
- Incidences by time:
- 3.14% for early poststroke seizures (≤7 days after stroke).
- 6.7% for late poststroke seizures (>7 days after stroke).
- Compared with non-IVT, IVT was not associated with poststroke seizures (pooled OR, 1.24; 95% CI, 0.75-2.05).
- Too few studies were identified to assess ORs for mechanical thrombectomy alone or in combination with IVT.
- Systematic review and meta-analysis of 25 studies among 13,753 patients with acute ischemic stroke.
- Main outcome: overall and treatment-specific pooled incidence of poststroke seizures after acute reperfusion therapy.
- Funding: None.
- Most studies took place in Western countries and China.
- Inability to tease out additive vs multiplicative effects of IVT and mechanical thrombectomy when combined.