- Almost 11% of adult patients who receive an opioid prescription for acute musculoskeletal injuries developed persistent opioid use.
- Chronic use is more than 4 times higher among high-risk patients than those at low risk.
Why this matters
- Avoiding opioid prescriptions after musculoskeletal injuries in patients with a history of substance use disorder, especially among older patients, could reduce the risk for persistent opioid use.
- Meta-analysis of 13 studies with 13,263,393 adult patients who received opioid prescriptions for acute musculoskeletal injuries.
- Funding: National Safety Council.
- Overall prevalence of persistent opioid use was 10.6%.
- 26.9% of high-risk patients experienced prolonged opioid use vs 5.9% of those at low risk (P<.001>
- For every 10-year increase in risk for persistent opioid use, factors associated with absolute risk increase (95% CIs) included:
- Older age: 1.1% (0.7%-1.5%).
- Physical comorbidity: 0.9% (0.1%-1.7%).
- Past or current substance use disorder: 10.5% (4.2%-19.8%).
- Risk for bias was a factor in most included studies.