- Maternal obesity, not gestational diabetes mellitus (GDM) alone, is linked to dyslipidemia during pregnancy.
Why this matters
- Maternal obesity, a modifiable risk factor, is associated with GDM, dyslipidemia, and adverse neonatal outcomes.
- Prospective observational study.
- Women with at least 1 maternal risk factor (obesity, family history of diabetes, personal history of polycystic ovarian syndrome, ethnicity, previous history of GDM, previous infant weighing ≥4.5 kg) for GDM were recruited at their first antenatal visit.
- 75-g oral glucose tolerance test performed at 26-28 weeks of gestation.
- Funding: None.
- 53.5% were diagnosed with GDM.
- Women diagnosed with GDM were more likely to have:
- Obesity: 70.4% vs 42.6% (P<.002 and>
- ≥2 risk factors for GDM: 38.9% vs 22.3% (P=.011).
- 60.2% had abnormal fasting plasma glucose (FPG) only;
- 27.8% had abnormal FPG and abnormal 1- or 2-hour measurement (or both); and
- 12% had normal FPG with abnormal post-glucose load test.
- Lower high-density lipoprotein levels (mmol/L): 1.8 vs 1.9 (P=.013); and
- Higher triglycerides (mmol/L): 2.2 vs 1.9 (P=.023).
- However, when stratified by maternal obesity, neither GDM nor obesity alone was associated with increased dyslipidemia risk.
- Single-center study; results may not be generalizable.