- Children exposed to gentamicin in infancy do not seem to experience effects on hearing thresholds at school age.
Why this matters
- Older studies had suggested some ototoxicity of neonatal gentamicin exposure, but the hearing tests used were less sensitive than the pure tone audiometry with extended high-frequency range used in this study.
- Median cumulative dose of gentamicin in infancy was 30 (interquartile range, 24-42) mg/kg.
- Median trough plasma level was 1.0 (interquartile range, 0.7-1.2) mg/L.
- At a median of 9 years of follow-up, the median midfrequency hearing threshold among exposed children was 2.5 (0-6.25) dB hearing level.
- Their median extended high-frequency range average hearing threshold was −1.7 (−5.0 to 5.0) dB hearing level.
- Both of these measures were in the normal range.
- After adjustment for birth weight, these children did not differ from a set of unexposed, age-matched controls.
- Included 219 children exposed neonatally to high-dose gentamicin regimen (2004-2012) and 33 unexposed age-matched controls.
- Funding: Northern Norway Regional Health Authority.
- Response rate from originally eligible exposed population was only 63%, creating potential selection bias.