Meta-analysis: slightly increased cancer risk with psoriasis

  • Vaengebjerg S & al.
  • JAMA Dermatol
  • 19.02.2020

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Psoriasis is associated with increased risk for several cancer types, according to a systematic review and meta-analysis.

Why this matters

  • This meta-analysis supports a previously reported link between psoriasis and cancer risk while clarifying the contributions of psoriatic arthritis and biologic therapies.

Key results

  • Patients with psoriasis had overall cancer prevalence of 4.78%.
    • Risk ratio (RR), 1.21 (95% CI, 1.11-1.33).
  • Risk (RR; 95% CI) was increased for:
    • Keratinocyte cancer: 2.28 (1.73-3.01).
    • Lymphomas: 1.56 (1.37-1.78).
    • Lung cancer: 1.26 (1.13-1.40).
    • Bladder cancer: 1.12 (1.04-1.19).
  • Cancer risk was not increased in patients with psoriasis treated with biologic agents (RR, 0.97; 95% CI, 0.85-1.10) or with psoriatic arthritis (RR, 1.02; 95% CI, 0.97-1.08).

Study design

  • 112 studies with 2,053,932 total patients were included in the meta-analysis.
  • Funding: None disclosed.

Limitations

  • Heterogeneity between included studies.