Meta-analysis: lichen planus is linked to increased risk for metabolic syndrome

  • Ying J & al.
  • PLoS One
  • 01.01.2020

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Lichen planus is associated with increased risk for metabolic syndrome, according to a systematic review and meta-analysis.

Why this matters

  • These results suggest that patients with lichen planus should be screened for metabolic disorders.

Key results

  • Patients with lichen planus had increased risk for metabolic syndrome:
    • Pooled OR: 2.81 (P<.00001>
  • In subgroup analysis, the pooled ORs for metabolic syndrome were greater in studies using International Diabetes Federation diagnostic criteria (OR, 4.65; P<.00001 and harmonized criteria p=".16)" than in studies using national cholesterol education program adult treatment panel iii>

Study design

  • 12 studies with 1422 participants (715 with lichen planus and 707 control participants) were included in the meta-analysis.
  • Funding: Zhejiang Medical and Health Science and Technology Program.

Limitations

  • Heterogeneity among included studies.