Meta-analysis: hypothyroidism is linked to all-cause mortality older people

  • Tsai TY & al.
  • J Clin Endocrinol Metab
  • 12.12.2019

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Hypothyroidism is associated with increased risk for all-cause mortality in patients aged ≥60 years, according to a systematic review and meta-analysis.

Why this matters

  • Studies of the association between hypothyroidism and mortality risk in older people have yielded conflicting results, necessitating a meta-analysis.

Key results

  • Hypothyroidism was associated with increased risk for all-cause mortality compared with euthyroidism (pooled relative risk [RR], 1.26; P<.001 style="list-style-type:circle;">
  • In subgroup analysis, increased risk was observed for patients with overt hypothyroidism (pooled RR, 1.10; P=.033), but not in patients with subclinical hypothyroidism (pooled RR, 1.14; P=.239).
  • Hypothyroidism was not associated with significantly increased risk for cardiovascular mortality compared with euthyroidism (pooled RR, 1.10; P=.492).
  • Study design

    • 1,114,638 participants aged ≥60 years from 27 cohort studies were included.
    • Funding: None.

    Limitations

    • Heterogeneity among included studies.