LRC: high BMI tied to complications after radical resection

  • Zhang X & al.
  • Surg Today
  • 18.02.2019

  • von David Reilly
  • Studien – kurz & knapp
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Takeaway

  • In patients undergoing radical resection for low-lying rectal cancer (LRC), higher BMI is associated with longer operative time, longer postoperative hospital stay, and increased incidence of postoperative complications.
  • Higher BMI in this setting was not linked to survival outcomes.

Why this matters

  • Radical resection is an optimal choice in patients with LRC.

Study design

  • Study to investigate the effect of increased BMI in surgical outcomes in 792 patients who underwent LRC resection.
  • Patients were stratified into 3 groups:
    • Controls: BMI 2 (n=624).
    • Overweight: BMI 25-30 kg/m2 (n=147).
    • Obese: BMI ≥30 kg/m2 (n=21).
  • Data source: colorectal cancer database of the Department of Gastrointestinal Surgery, West China Hospital, Sichuan University.
  • Funding: Science and Technology Support Program, Science and Technology Department of Sichuan Province.

Key results

  • High BMI was associated with significantly longer:
    • Operative time: P<.001.>
    • Postoperative hospital stay: P=.032.
  • Patients with increased BMI had significantly increased incidence of:
    • Pulmonary infection: P=.008.
    • Anastomotic leakage: P=.029.
    • Allergy: P=.017.
    • Long-term complication: P=.034.
    • Incisional hernia: P=.015.
  • No significant difference between groups in terms of OS (P=.734) or disease-free survival (P=.801).

Limitations

  • Retrospective data.