- Patients who received preoperative long-acting opioids before undergoing elective, noncardiac surgery had a longer LOS for inpatient surgeries and higher readmission rates for outpatient surgeries compared with opioid-naive patients.
- There were no significant differences between groups in rates of postoperative respiratory failure or major adverse cardiac events.
Why this matters
- The effect of preoperative long-acting opioid use on postoperative outcomes was unclear.
- Retrospective cohort study evaluated postoperative outcomes in 93,644 patients who underwent elective noncardiac surgeries and were either long-acting opioid users or were opioid-naive.
- Among included patients, 23,605 underwent inpatient surgeries and 70,039 underwent ambulatory surgeries.
- Funding: Anesthesia Research Fund of the New York University School of Medicine.
- Among inpatients, after adjusting for potential confounders, long-acting opioid use was significantly associated with prolonged postoperative hospital length of stay (incidence rate ratio, 1.1; P=.005).
- No significant association observed between long-acting opioids and adverse cardiac events (P=.13) or respiratory failure (P=.17).
- In patients undergoing ambulatory surgeries, long-acting opioids were significantly associated with hospital readmission (aOR, 2.1; P<.001>
- No significant association was observed between long-acting opioids use and adverse cardiac events (P=.6).
- Single-center study.
- Retrospective nature with possibility of confounding.
Coauthored with Antara Ghosh, PhD