Laser therapy shows long-term benefit for benign complex thyroid nodules

  • Døssing H & al.
  • Endocr Connect
  • 01.06.2019

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Laser therapy (LT) is associated with significant volume decreases and a 75% remission rate in patients with benign cystic thyroid nodules.

Why this matters

  • LT is considered safe and effective for inducing thyroid nodule necrosis, but its long-term efficacy for benign complex thyroid nodules was unclear.

Study design

  • 110 patients with a recurrent cytologically benign cystic (≥2 mL cyst volume) thyroid nodule were treated with LT and analyzed for outcomes.
  • 19 patients (17 within 6 months) had surgery after LT; median follow-up for the remaining 91 patients was 45 (range, 12-134) months.
  • Funding: None.

Key results

  • LT was associated with a decreased median nodule volume of 85% (range, 9.0-1.2 mL) (P<.001 style="list-style-type:circle;">
  • 22.4-19.4 mL; P=.05 in 19 patients who received surgery.
  • 7.3-0.8 mL; P<.001 in patients who did not receive surgery.>
  • 75% of patients experienced remission of the cystic part (volume ≤1 mL) after LT.
  • LT was associated with a median reduction in cyst volume from 5.5 to 0.0 mL (P<.001 in patients who did not receive surgery and to ml surgery.>
  • 71 patients experienced slight-to-moderate pain.
  • A higher number of aspirations before LT was associated with reduced cure rate of the cystic part of the thyroid nodule (P=.001).
    • Limitations

      • Single-arm study.