- Results from an open-label phase 3 randomized controlled trial suggest that adding induction chemotherapy (IC) with cisplatin/fluorouracil/docetaxel (TPF) to concurrent chemoradiotherapy (CCRT) is associated with superior survival outcomes in patients with locally advanced nasopharyngeal carcinoma (LA-NPC).
Why this matters
- Results suggest a promising treatment option for patients with LA-NPC, who experience a high recurrence rate.
- Adding IC to CCRT improved 5-year:
- Failure-free survival (77.4% vs 66.4%; HR, 0.64; P=.011).
- OS (85.6% vs 77.7%; HR, 0.61; P=.019).
- Distant failure-free survival (88% vs 79.8%, P=.030).
- Locoregional failure-free survival (90.7% vs 83.8%, P=.044).
- Grade 3/4 late toxicities were more common with IC+CCRT vs CCRT alone (72.8% vs 53.8%; P<.001>
- 480 patients with stage III-IVB (except T3-4N0) NPC, randomly assigned to receive CCRT with or without IC (n=241, 239).
- Funding: Shenzhen Main Luck Pharmaceuticals In.; Sun Yat-sen University; National Natural Science Foundation of China; Natural Science Foundation of Guang Dong Province; Health & Medical Collaborative Innovation Project of Guangzhou City; Innovation Team Development Plan of the Ministry of Education; Overseas Expertise Introduction Project for Discipline Innovation.
- Prognostic biomarkers not used for participant selection.
- Patients ≥60 years not included.