- A small meta-analysis finds that multiple injections of platelet-rich plasma (PRP) for knee osteoarthritis (KOA) are better than a single injection, but only for improved knee functionality, not pain.
Why this matters
- Although these findings are interesting, the evidence base remains scant.
- A meta-analysis of 5 randomized controlled trials (RCTs; N=301).
- Funding: None disclosed.
- Pain: no difference in single vs multiple (double or triple) injections for pain improvement: standardized mean difference (SMD), 0.61 (P=.48; I2=97%).
- Knee functionality: multiple injections at 6 months postinjection bested single injection for knee functionality: SMD, 2.29 (P=.01; I2=97%).
- Small number of RCTs, patients.