KOA: multiple PRP injections better than single injection in meta-analysis

  • Vilchez-Cavazos F & al.
  • Orthop J Sports Med
  • 01.12.2019

  • von Miriam Davis, PhD
  • Clinical Essentials
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Takeaway

  • A small meta-analysis finds that multiple injections of platelet-rich plasma (PRP) for knee osteoarthritis (KOA) are better than a single injection, but only for improved knee functionality, not pain.

Why this matters

  • Although these findings are interesting, the evidence base remains scant.

Study design

  • A meta-analysis of 5 randomized controlled trials (RCTs; N=301).
  • Funding: None disclosed.

Key results

  • Pain: no difference in single vs multiple (double or triple) injections for pain improvement: standardized mean difference (SMD), 0.61 (P=.48; I2=97%).
  • Knee functionality: multiple injections at 6 months postinjection bested single injection for knee functionality: SMD, 2.29 (P=.01; I2=97%).

Limitations

  • Small number of RCTs, patients.