- Patients with small-cell lung cancer (SCLC) and brain metastases treated with firstline stereotactic radiosurgery (SRS) alone had significantly better OS than those who received whole-brain radiotherapy (WBRT).
- However, they had worse time to central nervous system (CNS) progression (TTCP) in this cohort study.
Why this matters
- Although WBRT is standard therapy for SCLC with brain metastases, SRS alone may be appropriate for select patients.
- International, multicenter FIRE-SCLC cohort study.
- 710 patients with SCLC and brain metastases treated with firstline SRS and 219 patients treated with firstline WBRT.
- Funding: University of Colorado Cancer Center.
- Median OS was significantly better (P<.001 with brain metastasis vs>
- 1 lesion: 11.0 months.
- 2-4 lesions: 8.7 months.
- 5-10 lesions: 8.0 months.
- ≥11 lesions: 5.5 months.