- 30% of patients with hyperparathyroidism who underwent parathyroidectomy experienced persistently elevated parathyroid hormone (PTH) in a follow-up study at a tertiary hospital.
Why this matters
- The number of parathyroidectomy procedures is increasing over time, necessitating better understanding of patients who continue to have elevated PTH.
- 97% of patients had normalized calcium after surgery.
- 30% of patients had persistently elevated PTH after surgery.
- Persistently elevated PTH was not significantly associated with sex, age, BMI, or gland weight.
- Patients with persistently elevated PTH had lower presurgery vitamin D levels (26.1 vs 35.6 ng/mL; P=.019) and higher presurgery PTH levels (156.5 vs 102.5 pg/mL; P<.001 compared with patients normalized pth.>
- Presurgery calcium was inversely associated with postsurgery PTH (P=.002).
- 407 patients who underwent parathyroidectomy for primary hyperparathyroidism from the Carolina Data Warehouse were included.
- 144 had PTH measurements within 3-18 months of surgery.
- Funding: National Center for Advancing Translational Sciences.
- Retrospective study design.