- Compared with having a normal BMI, values starting at high-normal and greater are tied to increased risk for early heart failure (HF) in young women.
- Risk increase is 5-fold with BMI at or over 35 kg/m2.
Why this matters
- In Sweden, where this study was conducted, HF rates are increasing in the younger population.
- Increasing BMI is a global issue.
- Vs BMI 20-2, risks (adjusted HRs, 95% CIs) for HF by BMI (kg/m2) were:
- ≥35: 4.51 (3.63-5.61).
- With further adjustments, HRs for HF associated specifically with coronary heart disease, diabetes, or hypertension increased even more with BMI in overweight and obese ranges.
- Prospective, registry-based cohort study with 1,374,031 women, aged 18-45 (mean 27.9 [standard deviation, 4.9]) years, who delivered a child, 1982-2014.
- Maximum follow-up was 33 years.
- Mean age at HF diagnosis was
- Mean BMI, 23.7 kg/m2, and 68.5% had normal BMI.
- Funding: Swedish Heart and Lung Foundation; others.
- Some comorbidities were self-reported.
- Follow-up data on weight lacking.