Hashimoto's thyroiditis: acoustic structure quantification predicts hypothyroidism

  • Lee JY & al.
  • Eur Radiol
  • 15.04.2019

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Acoustic structure quantification (ASQ), a method for assessment of thyroid parenchymal echogenicity using ultrasonography, is predictive of overt hypothyroidism in patients with Hashimoto’s thyroiditis.

Why this matters

  • ASQ is a potentially useful tool for patient stratification.

Key results

  • 67.7% of patients experienced overt hypothyroidism.
  • ASQ average (P<.001 standard deviation and focal disturbance ratio were associated with increased risk for overt hypothyroidism in kaplan-meier analysis.>
  • High ASQ average (HR, 1.03; P=.037) and high thyroid-stimulating hormone (TSH) levels (HR, 1.07; P=.041) were associated with overt hypothyroidism in multivariate analysis.
  • ASQ measurements had high interobserver agreement (range, 0.97-0.98; 95% CI, 0.97-0.99).
  • ASQ average was correlated with levels of TSH (r=0.569; P<.001 thyroperoxidase antibody and thyroglobulin>

Study design

  • 90 patients with Hashimoto’s thyroiditis were analyzed using ASQ and followed-up for development of overt hypothyroidism.
  • Funding: Soonchunhyang University Research Fund.

Limitations

  • Small patient sample size.
  • Few patients were diagnosed histologically.