- Acoustic structure quantification (ASQ), a method for assessment of thyroid parenchymal echogenicity using ultrasonography, is predictive of overt hypothyroidism in patients with Hashimoto’s thyroiditis.
Why this matters
- ASQ is a potentially useful tool for patient stratification.
- 67.7% of patients experienced overt hypothyroidism.
- ASQ average (P<.001 standard deviation and focal disturbance ratio were associated with increased risk for overt hypothyroidism in kaplan-meier analysis.>
- High ASQ average (HR, 1.03; P=.037) and high thyroid-stimulating hormone (TSH) levels (HR, 1.07; P=.041) were associated with overt hypothyroidism in multivariate analysis.
- ASQ measurements had high interobserver agreement (range, 0.97-0.98; 95% CI, 0.97-0.99).
- ASQ average was correlated with levels of TSH (r=0.569; P<.001 thyroperoxidase antibody and thyroglobulin>
- 90 patients with Hashimoto’s thyroiditis were analyzed using ASQ and followed-up for development of overt hypothyroidism.
- Funding: Soonchunhyang University Research Fund.
- Small patient sample size.
- Few patients were diagnosed histologically.