Gallbladder cancer: jaundice tied to poor resection outcomes

  • Dasari BVM & al.
  • J Surg Oncol
  • 01.09.2018

  • von Miriam Davis, PhD
  • Studien – kurz & knapp
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Takeaway

  • Patients with gallbladder cancer (GBC) presenting with obstructive jaundice have poorer morbidity and mortality after radical surgical resection (which includes portal lymphadenectomy and bile duct resection to achieve negative margins).

Why this matters

  • Jaundiced patients should be advised of adverse outcomes.

Study design

  • Meta-analysis of 7 studies (n=1960) that met eligibility criteria after a search of PubMed, MEDLINE, EMBASE, CINAHL, and AMED.
  • OS was the primary outcome.
  • Funding: None disclosed.

Key results

  • Jaundiced vs nonjaundiced patients had shorter OS (HR, 2.21; P<.001>
  • Jaundiced vs nonjaundiced patients were less likely to have resectable disease (OR, 0.27; P<.001>
  • Jaundiced vs nonjaundiced patients had greater odds of postoperative morbidity (P<.001 bile leak and posthepatectomy liver failure>

Limitations

  • High heterogeneity across studies.
  • Small number of studies, patients.
  • Number of randomized studies not specified.