- Almost one-fifth of US adults with diabetes mellitus (DM) have residual hypertriglyceridemia (HTG) despite statin use, and they are at increased atherosclerotic cardiovascular disease (ASCVD) risk.
Why this matters
- HTG is significantly associated with future ASCVD risk.
- Study of 1448 US adults aged ≥20 years with diabetes in 2007-2014 National Health and Nutrition Examination Survey, comparing prevalence of borderline HTG (TG 150-199 mg/dL) and HTG (≥200 mg/dL) by statin use and low-density lipoprotein cholesterol (LDL-C) levels.
- Funding: Amarin Pharma, Inc.
- Prevalences: borderline HTG, 20.1% (projected to 4.9 million population); HTG, 22.5% (5.5 million).
- HTG was found in 19.5% of statin users and 25.3% of nonstatin users.
- In those with LDL-C
- Prevalences of 10-year estimated ASCVD risks ≥7.5% were:
- 68.7% with normal TG,
- 62.7% with borderline HTG, and
- 77.5% with HTG.
- One-third with HTG overall and ~40% of statin users had ASCVD risk ≥20%.
- Results limited to population studied.
- No information regarding duration, intensity, and adherence of statin use.