Cushing's disease, acromegaly: Gamma Knife reasonably effective in children

  • Shrivastava A & al.
  • World Neurosurg
  • 18.02.2019

  • von Brian Richardson, PhD
  • Clinical Essentials
Der Zugang zum gesamten Inhalt dieser Seite ist nur Angehörigen medizinischer Fachkreise vorbehalten. Der Zugang zum gesamten Inhalt dieser Seite ist nur Angehörigen medizinischer Fachkreise vorbehalten.

Takeaway

  • A small, retrospective study finds that Gamma Knife radiosurgery (GKRS) is associated with remission rates of 80% and 42%, respectively, in pediatric patients with Cushing’s disease or acromegaly with pituitary adenomas.

Why this matters

  • Few studies have analyzed the role of stereotactic radiosurgery in pediatric patients.

Key results

  • In patients with Cushing’s disease, GKRS was associated with an 80% remission rate and 88% tumor control rate.
  • In patients with acromegaly, GKRS was associated with a 42% remission rate (P=.002 vs Cushing’s disease) and 92% tumor control rate (P=.07 vs Cushing’s disease).
  • The probability of cumulative remission-free survival was better in the Cushing’s disease group compared with the acromegaly group (P=.002)
  • 21% of patients with Cushing’s disease and 17% of patients with acromegaly experienced new pituitary hormone deficiency.
  • Age

Study design

  • 24 patients with Cushing’s disease and 12 patients with acromegaly were treated with GKRS and analyzed for outcomes.
  • Funding: International Gamma Knife Research Foundation.

Limitations

  • Retrospective study.
  • Small patient sample size.