- A small, retrospective study finds that Gamma Knife radiosurgery (GKRS) is associated with remission rates of 80% and 42%, respectively, in pediatric patients with Cushing’s disease or acromegaly with pituitary adenomas.
Why this matters
- Few studies have analyzed the role of stereotactic radiosurgery in pediatric patients.
- In patients with Cushing’s disease, GKRS was associated with an 80% remission rate and 88% tumor control rate.
- In patients with acromegaly, GKRS was associated with a 42% remission rate (P=.002 vs Cushing’s disease) and 92% tumor control rate (P=.07 vs Cushing’s disease).
- The probability of cumulative remission-free survival was better in the Cushing’s disease group compared with the acromegaly group (P=.002)
- 21% of patients with Cushing’s disease and 17% of patients with acromegaly experienced new pituitary hormone deficiency.
- 24 patients with Cushing’s disease and 12 patients with acromegaly were treated with GKRS and analyzed for outcomes.
- Funding: International Gamma Knife Research Foundation.
- Retrospective study.
- Small patient sample size.