- Early data suggest there is no 2019 novel coronavirus (COVID-19) vertical transmission in late pregnancy among pregnant women with confirmed COVID-19 pneumonia.
- A related editorial calls the findings "valuable" for these emergent circumstances.
Why this matters
- Counseling, screening, and follow-up are important in pregnant patients.
- Neonates born to women with confirmed COVID-19 should be isolated for ~14 days from birth, and breastfeeding and close maternal contact should be avoided.
- 9 third trimester pregnancies (range, 36-39 weeks, +4 days); age range, 26-40 years; 6/9 testing samples.
- 9/9 had cesarean sections.
- Symptoms: low fever (36.5-38.8°C) without chills (n=7 before delivery; other 2 developed fever postpartum); cough (n=4), myalgia (n=3), sore throat (n=2), malaise (n=2), gastrointestinal illness (n=1), shortness of breath (n=1).
- Pregnancy complications: fetal distress (n=2), premature rupture of membranes (n=2), gestational diabetes (n=1), preeclampsia (n=1).
- Labs: lymphopenia (9 cells/L; n=5), C-reactive protein (>10 mg/L; n=6), elevated alanine aminotransferase or aspartate aminotransferase (n=3), low/normal white cell count (n=7).
- 8/9: typical COVID-9 chest CT images.
- 9/9 live births, no neonatal asphyxia.
- 9/9 had 1-min Apgar scores of 8-9 and 5-min Apgar scores of 9-10.
- Retrospective case review describing clinical characteristics, potential intrauterine vertical transmission of COVID-19 in pregnant women hospitalized with confirmed COVID-19 pneumonia.
- Funding: Hubei Science and Technology Plan; Wuhan University Medical Development Plan.
- Small sample.
- Early pregnancy transmission potential unclear.
- Intrapartum, uterine ascending transmission risk unclear.