- Children diagnosed with inflammatory bowel disease (IBD) were significantly more likely to attempt suicide or develop a psychiatric disorder compared with children without IBD.
- Risk was especially high for ADHD, autism, mood, anxiety, eating, or personality disorders.
Why this matters
- Overall risk was highest in first year of follow-up, but remained significant for >5 years.
- Results were validated by sibling comparison.
- Population-based cohort study (childhood-onset IBD; n=6464; matched reference, n=323,200).
- Median follow-up: 9 years.
- Funding: The Swedish Cancer Society; others.
- The IBD group was diagnosed with:
- ulcerative colitis (n=3228),
- Crohn's disease (n=2536), or
- unclassified IBD (n=700).
- The IBD group (vs reference) was at increased risk for:
- any psychiatric disorder (HR, 1.6; 95% CI, 1.5-1.7),
- suicide attempts (HR, 1.4; 95% CI, 1.2-1.7),
- mood disorders (HR, 1.6; 95% CI, 1.4-1.7),
- anxiety disorders (HR, 1.9; 95% CI, 1.7-2.0),
- eating disorders (HR, 1.6; 95% CI, 1.3-2.0),
- personality disorders (HR, 1.4; 95% CI, 1.1-1.8),
- ADHD (HR, 1.2; 95% CI, 1.1-1.4), and
- autism spectrum disorders (HR, 1.4; 95% CI, 1.1-1.7).
- No direct measurements for IBD severity.
- Severity of IBD may be associated with psychiatric disorders.
Coauthored with Chitra Ravi, MPharm