- Cancer patients with chemotherapy-related cognitive difficulties saw greater improvement with a computer-assisted cognitive rehabilitation program supervised by a neuropsychologist than with home cognitive self-exercises or simple telephone follow-up.
Why this matters
- Effective treatments for cancer-related cognitive impairment are lacking.
- Proportion of patients with 7-point improvement in perceived cognitive impairment score:
- 75.0% with computer-assisted cognitive rehabilitation (P=.12 and P=.09, respectively);
- 59.1% with home cognitive self-exercise control; and
- 56.9% with telephone follow-up control.
- Vs controls, computer-assisted cognitive rehabilitation netted greater mean changes in:
- perceived cognitive impairment (16.3 vs 11.1 and 9.1; P=.02);
- perceived cognitive abilities (5.3 vs 1.8 and 2.7; P<.01>
- working memory (1.3 vs 1.1 and 0.4; P=.03);
- cognition-related QoL (5.1 vs 2.6 and 3.8; P=.01); and
- depression symptoms (−6.5 vs −1.7 and −2.3; P=.03).
- French multicenter, randomized controlled trial among 167 patients with cancer (median age, 51 years) with cognitive complaints during/within 5 years of completing chemotherapy.
- Three 12-week cognitive rehabilitation programs:
- computer-assisted cognitive rehabilitation with neuropsychologist,
- home cognitive self-exercises (control), and
- telephone follow-ups (control).
- Main outcome: 7-point improvement in Functional Assessment of Cancer Therapy-Cognitive Function perceived cognitive impairment score.
- Funding: Ligue Nationale Contre le Cancer.
- No long-term follow-up.
- Majority had breast cancer and received hormone therapy.
- Multiple testing.