- Inpatients with cannabis use disorder were more than 50% as likely to have a primary diagnosis of epilepsy.
Why this matters
- Possible increasing off-label use of unregulated cannabidiol, marijuana and unknown cerebrovascular effects of long-term cannabis use.
- Risk for epilepsy hospitalization higher for patients with vs without cannabis use disorder after adjustment for:
- Demographics (OR, 1.556; P<.001>
- All suspected risk factors excluding other substance use disorders (OR, 1.490; P<.001 and>
- Demographics and all risk factors including tobacco, opioid, amphetamine, cocaine, alcohol abuse disorders (OR, 1.420; P<.001>
- Younger (P<.001>
- More often male and African American (P<.001 for both and>
- More commonly had preexisting epilepsy risk factors (brain tumor, meningitis, encephalitis, cerebral palsy, stroke, developmental disorders; P<.001 for all>
- Retrospective cross-sectional cohort study of Nationwide Inpatient Sample 2010-2014, patients aged 15-54 years:
- 657,072 with primary diagnosis of epilepsy.
- 67,575,568 without epilepsy.
- Main outcome: epilepsy hospitalization.
- Funding: None.
- Study establishes only correlation.
- Lack of information on dose, strains, preparations, reasons for use.