- Higher fruit intake during adolescence and whole wheat bread intake during midlife were associated with reduced risk for monoclonal gammopathy of undetermined significance (MGUS).
- Higher intake of fruit during later life was associated with reduced risk for progression from MGUS to multiple myeloma (MM).
Why this matters
- Obesity has been linked to risk for MM, which may in turn suggest a potential link between diet and risk for MM.
- Study to investigate an association between diet risk for MGUS and LC-MGUS using data (N=5764) from the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES Study) of individuals born 1907-1935.
- Participants completed questionnaires regarding food intake during adolescence and midlife, as well as current dietary habits.
- Funding: NIH; National Institute on Aging; Icelandic Heart Association; Icelandic Parliament.
- During adolescent years:
- Reduced risk for MGUS in participants with fruit intake ≥3 times/week (OR, 0.62; 95% CI, 0.41-0.95).
- During midlife:
- Reduced risk for MGUS with whole wheat bread intake ≥5 times/week (OR, 0.75; 95% CI, 0.57-0.99).
- During later life:
- Reduced risk of progressing from MGUS to MM with fruit intake ≥3 times/week (OR, 0.34; 95% CI, 0.13-0.89).
- Retrospective data.