Can diet help prevent progression from MGUS to MM?

  • Thordardottir M & al.
  • PLoS One
  • 01.01.2018

  • aus David Reilly
  • Studien - kurz & knapp
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Takeaway

  • Higher fruit intake during adolescence and whole wheat bread intake during midlife were associated with reduced risk for monoclonal gammopathy of undetermined significance (MGUS).
  • Higher intake of fruit during later life was associated with reduced risk for progression from MGUS to multiple myeloma (MM). 

Why this matters

  • Obesity has been linked to risk for MM, which may in turn suggest a potential link between diet and risk for MM.

Study design

  • Study to investigate an association between diet risk for MGUS and LC-MGUS using data (N=5764) from the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES Study) of individuals born 1907-1935.
  • Participants completed questionnaires regarding food intake during adolescence and midlife, as well as current dietary habits.
  • Funding: NIH; National Institute on Aging; Icelandic Heart Association; Icelandic Parliament.

Key results

  • During adolescent years:
    • Reduced risk for MGUS in participants with fruit intake ≥3 times/week (OR, 0.62; 95% CI, 0.41-0.95).
  • During midlife:
    • Reduced risk for MGUS with whole wheat bread intake ≥5 times/week (OR, 0.75; 95% CI, 0.57-0.99).
  • During later life:
    • Reduced risk of progressing from MGUS to MM with fruit intake ≥3 times/week (OR, 0.34; 95% CI, 0.13-0.89).

Limitations

  • Retrospective data.