- A 12-month program of aerobic exercise and muscle strengthening prevents loss of bone mineral density (BMD) in premenopausal women with breast cancer who maintain or gain lean muscle mass, but not in those who lose lean muscle mass.
Why this matters
- Maintaining or gaining lean muscle mass should be a target of an exercise/strengthening programs to prevent BMD loss.
- Randomized controlled trial (n=206) of a 12-month exercise/strengthening program or control group for premenopausal women aged ≤55 years at breast cancer diagnosis who received adjuvant chemotherapy within the prior 2 years.
- The control group received a monthly health newsletter.
- BMD was assessed by dual energy X-ray absorptiometry at baseline and 1 year.
- Funding: NIH.
- No difference in lumbar spine BMD between exercise/strengthening group and control patients, with both groups losing mean BMD (−0.008±0.003 vs −0.014±0.003 g/cm2; P=.24).
- A subgroup of the exercise/strengthening group that maintained or gained lean mass prevented lumbar spine BMD loss relative to control patients (mean change, +0.001±0.005 g/cm2 vs −0.014±0.005 g/cm2, respectively; P=.03);
- No difference in BMD loss between controls and the subgroup that lost lean mass.
- Lean muscle mass not defined.