APA 2018—Anti-inflammatory agents linked to risk for depression after first-time stroke


  • Conference Reports
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Takeaway

  • Taking anti-inflammatory medication after stroke was associated with a decreased risk for early-onset depression.
  • Taking acetylsalicylic acid (ASA) or an NSAID was associated with elevated risk for late-onset depression.

Why this matters

  • Treatment with an anti-inflammatory agent in combination with a statin immediately after stroke may aid in preventing a subsequent stroke event, as well as in preventing early-onset depression.

Key results

  • HRs for early depression (depression at 1 month) in stroke patients taking an ASA, an NSAID, or statins were 0.67, 0.83, and 0.70, respectively, in comparison with stroke patients taking no medication.
  • Risk for late depression (depression at 1 year) was elevated in stroke patients taking either an ASA or an NSAID vs no medication (HR, 1.31 and 1.30, respectively).

Study design

  • Researchers compared data from 147,487 Danish stroke patients with data from 160,235 patients without a history of stroke.
  • Funding: Danish Tryg Foundation, Danish Heart Association.

Limitations

  • This was a retrospective study, meaning it is not appropriate to conclude causality.