Anti-Müllerian hormone levels predict live birth success following embryo transfer

  • Ciepiela P & al.
  • Hum Reprod
  • 14.11.2019

  • von Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Higher anti-Müllerian hormone (AMH) concentration in follicular fluid (FF) is associated with improved odds of live birth after single embryo transfer (SET).

Why this matters

  • This study supports and clarifies the link between high AMH levels and improved chance of pregnancy.

Key results

  • AMH (OR, 1.134; P=.009), luteinizing hormone (OR, 1.573; P=.000), and testosterone (OR 1.106, P=.041) levels were associated with odds of top-quality blastocysts, whereas follicle-stimulating hormone (OR, 0.631; P=.000) and androstenedione (OR, 0.936; P=.042) levels were inversely associated.
  • FF AMH levels were associated with increased odds of live birth (OR, 1.934; P=.000).
  • FF AMH levels had 91.2% sensitivity and 91.7% specificity for predicting live birth.

Study design

  • 106 transferred embryos with matching FF samples were analyzed for AMH and FSH levels and correlations with SET outcomes.
  • Funding: National Science Centre of Poland.

Limitations

  • Cross-sectional study design.
  • Some patients with polycystic ovary syndrome were included, which may have biased the results.