Takeaway
- Patients with anal adenocarcinoma (AA) who undergo abdominoperineal resection (APR) have better survival if the surgery occurs within 6 months of receiving chemoradiotherapy (CRT) compared with a longer interval.
Why this matters
- AA is a rare cancer, and there are no evidence-based treatment guidelines for it. This is the largest observational study of the condition to date.
Study design
- Retrospective analysis of 24,461 patients (95.2% squamous cell carcinoma [AS]; 4.8% AA).
- Funding: None disclosed.
Key results
- Median OS was lower in AA vs AS (72.5 vs 143.8 months; P<.001>
- 96.2% of patients with AA were treated with APR within 6 months of CRT.
- Patients with AA who underwent APR within 6 months of CRT had a longer median survival than those who had APR ≥6 months after CRT (88.3 vs 58.1 months; P<.001>
- The
Limitations
- Retrospective analysis.
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