- Advisory Committee on Immunization Practices (ACIP, 2019) updated HPV vaccine recommendations, highlighting the need for shared clinical decision-making in adults ≥26 years.
Why this matters
- HPV vaccine effectiveness (VE) may be low among adults with multiple lifetime sex partners and/or previous infections with vaccine-type HPV.
- Discuss sexual history to determine potential benefit of HPV vaccination; consider HPV vaccine in adults aged 27-45 years with new sexual partners, no indication of prior exposure as both are HPV risk factors.
- Routine HPV vaccination recommendations in children, adolescents, young adults aged 9-26 years remain unchanged.
- Recommendations in pregnant women have not changed.
- HPV vaccination is not recommended for adults >45 years.
- Testing is unavailable to determine immunity status, continued susceptibility to vaccine-type HPV.
- Most adults have been exposed to some HPV types, although not those targeted by vaccination.